Dr. Tami Martino

Research Platforms

Heart Failure, Circadian Rhythms, Molecular Biology of Heart Disease, Translational Research, Cardiovascular Physiology, Proteomics of Heart Disease

Academic Background

B.Sc – McMaster University MSc, PhD – University of Toronto

Research Institutes worked at

Hospital for Sick Children Toronto; Toronto General Hospital; MARS Discovery

Funding   

Canadian Fund for Innovation (CFI) Infrastructure Grant – PI
   Canadian Institute of Health Research Operating Grant (CIHR) – PI
   Heart and Stroke Foundation of Ontario, Operating Grants – PI
   Ontario Cancer Biomarker Network – Co-applicant with G. Bjarnason

Research Interests

• Circadian regulation of cardiac growth and remodeling in cardiovascular diseases such as myocardial infarction (heart attacks), hypertension, cardiac hypertrophy.
• Circadian dyssynchrony and its important role in human health – sleep disorders, shift work
• Day/night or circadian variation in physiologic and molecular processes, and its unique relevance to biomarker discovery and molecular diagnostics.
• State-of-the-art high throughput technologies including microarrays, mass spectrometry proteomics, and bioinformatics.

Facilities/Unique Equipment

Cardiovascular transgenic laboratory
Cardiovascular physiology suite: cardiovascular disease models, echocardiography, hemodynamics, pathology, immunohistochemistry
Circadian rhythms laboratory: Colbourn actigraphy, diurnal dyssynchrony, circadian mutant mice, chronotherapy models of heart disease, chronobiomarkers
Proteomics: 2D dige, mass spectrometry, BioRad ChemiDoc Imaging System, BioRad 1D gel apparatus
Flow cytometry, Accuri C6
Molecular genomics: microarrays, RTPCR Viia7 Machine, spectrophotometer Nanodrop, genotyping facilities

Media and Links

Distinguished Chair in Molecular Cardiovascular Research, University of Guelph

Director, Centre for Cardiovascular Investigations (CCVI)

Career Investigator Heart & Stroke Foundation: Circadian Medicine & Heart Health

Professor, Biomedical Sciences, OVC Departmental Faculty Page

Simple changes in ICU can help heart attack patients: Study

Sun News Article: “Proper sleep speeds up recovery after heart attack: Study”

Guelph News Article: “Tick Tock Goes the Heart”

Guelph News Article: “Heart Medication Best at Bedtime”

CTV Media Report: The most effective time of day to take medication

The Globe and Mail Article: “Your heart medication is more effective at bedtime”

Guelph News Article: “U of G collaborations look for the causes of cardiovascular disease”

Experimental Biology 2011 Article

Guelph News Article: “Watch Your Circadian Clock to Help Your Ticker”

Publications (since 2000)

42. Cristine J Reitz, Faisal J Alibhai , Bruna Gazzi de Lima Seolin, Ashley Susan Nemec-Bakk, Neelam Khaper, Tami A Martino. (2020) Circadian Mutant Mice with Obesity and Metabolic Syndrome are Resilient to Cardiovascular Disease. Am J Physiol Heart Circ Physiol. 2020 Sep 28. PMID: 32986958
41. Priya Mistry, Cristine J Reitz, Tarak Nath Khatua, Mina Rasouli, Kaitlyn Oliphant, Martin E Young, Emma Allen-Vercoe, Tami A Martino. (2020) Circadian influence on the microbiome improves heart failure outcomes. J Mol Cell Cardiol. Sep 19;149:54-72. PMID: 32961201
40. Sobuj Mia, Mariame S Kane , Mary N Latimer , Cristine J Reitz , Ravi Sonkar, Gloria A Benavides, Samuel R Smith, Stuart J Frank , Tami A Martino , Jianhua Zhang , Victor M Darley-Usmar , Martin E Young. (2020) Differential effects of REV-ERBa/b agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption. Am J Physiol Heart Circ Physiol. Jun 1PMID: 32357113
39. Tami A Martino, Mary E Harrington. J Biol Rhythms. (2020) The Time for Circadian Medicine. J Biol Rhythms. Oct;35(5):419-420. PMID: 32746705
38. Cristine J Reitz , Faisal J Alibhai , Tarak N Khatua , Mina Rasouli , Byram W Bridle , Thomas P Burris, Tami A Martino. (2019) SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome. Commun Biol. Oct 3;2:353. PMID: 31602405
37. Inna Rabinovich-Nikitin , Brooke Lieberman , Tami A Martino , Lorrie A Kirshenbaum, Circulation. (2019) Circadian-Regulated Cell Death in Cardiovascular Diseases. Circulation. Feb 12;139(7):965-980.PMID: 30742538
36. Austin T H Duong , Cristine J Reitz , Emma L Louth , Samantha D Creighton, Mina Rasouli , Ashley Zwaiman , Jeffrey T Kroetsch , Steffen-Sebastian Bolz , Boyer D Winters , Craig D C Bailey , Tami A Martino. (2019) The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock 19/19 Mice With Implications for Circadian Medicine. Sci Rep. Mar 21;9(1):4994. PMID: 30899044
35. Khaper N, Bailey CDC, Ghugre NR, Reitz C, Awosanmi Z, Waines R, Martino TA. (2018) Implications of disturbances in circadian rhythms for cardiovascular health: A new frontier in free radical biology Free Radic Biol Med. 1;119:85-92. PMID: 29146117
34. Alibhai FJ, LaMarre J, Reitz CJ, Tsimakouridze EV, Kroetsch JT, Bolz SS, Shulman A, Steinberg S, Burris TP, Oudit GY, Martino TA. (2017) Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease. J Mol Cell Cardiol. 105:24-37. PMID: 28223222
33. Alibhai FJ, Reitz CJ, Peppler WT, Basu P, Sheppard P, Choleris E, Bakovic M, Martino TA. (2017) Female Clockd19/d19 Mice are Protected from the Development of Age-Dependent Cardiomyopathy. Cardiovasc Res. 1;114(2):259-271. PMID: 28927226
32. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, et al. Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptacek LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. (2017) Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms.32(5):380-393. PMID: 29098954
31. Mistry P, Duong A, Kirshenbaum L, Martino TA. (2017) Cardiac Clocks and Preclinical Translation. Heart Fail Clin. 13(4):657-672. Review. PMID: 28865775
30. Khaper N, Bailey CDC, Ghugre NR, Reitz C, Awosanmi Z, Waines R, Martino TA. (2017) Implications of disturbances in circadian rhythms for cardiovascular health: A new frontier in free radical biology. Free Radic Biol Med. pii: S0891-5849(17)31199-1. Review. PMID: 29146117
29. Bennardo M, Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Podobed P, Reitz CJ, Pyle WG, Simpson JA, Martino TA. (2016) Day-Night Dependence of Gene Expression and Inflammatory Responses in the Remodeling Murine Heart post-Myocardial Infarction. Am J Physiol Regul Integr Comp Physiol.:ajpregu.00200.2016. PMID: 27733386
28. Martino TA, Young ME. (2015) Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology. J Biol Rhythms. [Epub ahead of print]
27. Tsimakouridze EV, Alibhai FJ, Martino TA. (2015). Therapeutic applications of circadian rhythms for the cardiovascular system. Front. Pharmacol. 6:77. Published online March 26, 2015.
26. Alibhai FJ, Tsimakourdize EV, Reitz CJ, Pyle G, Martino TA. (2015). Consequences of Circadian and Sleep Disturbances for the Cardiovascular System Canadian Journal of Cardiology. Published online January 26, 2015.
25. Young ME, Brewer RA, Peliciari-Garcia RA, Collins HE, He L, Birky TL, Peden BW, Thompson EG, Ammons BJ, Bray MS, Chatham JC, Wende AR, Yang Q, Chow CW, Martino TA, Gamble KL. (2014) Cardiomyocyte-specific BMAL1 plays critical roles in metabolism, signaling, and maintenance of contractile function of the heart. J Biol Rhythms. Aug;29(4):257-76.
24. Podobed PS, Alibhai FJ, Chow CW, Martino TA. (2014). Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data. PLoS One. 2014 Aug 14;9(8):e104907.
23. Podobed P, Pyle WG, Ackloo S, Alibhai FJ, Tsimakouridze EV, Ratcliffe WF, Mackay A, Simpson JA, Wright DC, Kirby G, Young ME, Martino TA. (2014). The Day/Night Proteome in the Murine Heart. Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R121-37.
22. Alibhai FJ, Tsimakouridze EV, Reitz CJ, Pyle WG, Martino TA. (2014). ‘The Cardiac Clock’ in the Role of the Circadian Clock in Health and Disease. Springer APS. In Press.
21. Alibhai FJ, Tsimakouridze EV, Chinnappareddy N, Wright DC, Billia F, O’Sullivan L, Pyle WG, Sole MJ, Martino TA. (2014). Short Term Disruption of Diurnal Rhythms Following Murine Myocardial Infarction Adversely Affects Long Term Myocardial Structure and Function. Circulation Research. 2014 May 23;114(11):1713-22.
20.- Editorial Focus by Sharma UC and Canty JM Jr. (2014). Myocardial repair around-the-clock. Commentary on Alibhai F.J. et al.,Short Term Disruption of Diurnal Rhythms Following Murine Myocardial Infarction Adversely Affects Long Term Myocardial Structure and Function. Circ Res. 2014 May 23;114(11):1713-22. (see above)
19. Tsimakouridze EV, Straume M, Podobed PS, Chin H, Lamarre J, Johnson R, Antenos M, Kirby GM, Mackay A, Huether P, Simpson JA, Sole M, Gadal G, Martino TA. (2012). Chronomics of pressure overload-induced cardiac hypertrophy in mice reveals altered day/night gene expression and biomarkers of heart disease. Chronobiology International 29: pp. 810-821.
18. Podobed P, Kirby G, Martino T.A. (2012). Circadian proteomics and its unique advantage for discovery of biomarkers of heart disease. In TK Man, RJ Flores (Eds.) “Proteomics. Human Diseases and Protein Functions”, pp. 65-88. InTech.
17. Martino T.A., et al. (2011). The Primary Benefits of Angiotensin Converting Enzyme Inhibition on Cardiac Remodelling Occur During Sleep-Time in Murine Pressure Overload Hypertrophy. Journal of the American College of Cardiology, May17;57(20):2020-2028.
16.- Editorial Focus by Jugdutt BI (2011). Optimizing Pharmacotherapy for Limiting Cardiovascular Remodeling. A Matter of Timing Therapy to Match Biology. Editorial Commentary on Martino T.A. et al., The Primary Benefits of ACE Inhibition, J Am Coll Cardiol, 2011;57:2029-30 (see above).
15. M.J. Sole and Martino, T.A. (2010). Diurnal Molecular Rhythms: Unrecognized Critical Determinants of Cardiovascular Health and Disease. In T.D. Bradley and J.S. Floras (Eds.) Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease. Chapter 1. Pages 1-14.
14. Martino T.A., and Sole M.J. (2009). Molecular Time. An Often Overlooked Dimension to Cardiovascular Disease. Circulation Research. Invited Review. Nov 20;105(11):1047-1061.
13. – Editorial Focus by Karyn A. Esser and Martin E. Young (2009) on Highlighted Topic, The Role of Clock Genes in Cardiometabolic Disease. J. Appl. Physiol. 107:1316-1317.
12. Sole M.J., and Martino T.A. (2009). Diurnal Physiology: Core Principles with Application to the Pathogenesis, Diagnosis, Prevention and Treatment of Myocardial Hypertrophy and Failure. Journal of Applied Physiology. Invited Review. 2009, Oct;107(4):1318-27, Epub 2009 Jun 25.
11. Chalmers J.A., Martino T.A., Tata N, Ralph M.R., Sole M.J., Belsham D.D. (2008). Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1). American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 2008 Nov;295(5):R1529-1538. Epub 2008 Sept 3.
10. Chalmers J.A., Lin SYJ, Martino T.A., Arab S, Liu Peter, Husain M, Sole M.J., Belsham D.D. (2008). Diurnal Profiling of NeuroEndocrine Genes in Murine Heart and Shift in Proopriomelanocortin Gene Expression with Pressure-Overload Cardiac Hypertrophy. Journal of Molecular Endocrinology, 2008 Sept;41(3):117-124. Epub 2008 June 12.
9. Martino T.A, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph, MR, and Sole MJ. (2008). Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters. American Journal of Physiology- Regulatory Integrative and Comparative Physiology, 2008 May;294(5):1675-1683. Epub 2008 Feb 13.
8. – Editorial Focus by Fred W. Turek (2008) on “Circadian Rhythm Disorganization Produces Profound Cardiovascular and Renal Disease in Hamsters: by Martino et al. Am. J. Physiol. Regul. Integr. Comp. Physiol 2008 May;294(5):1672-4. Epub 2008 Mar 19
7. Martino, T.A., Tata N., Bjarnason G.A., Straume M., and Sole M.J. (2007). Diurnal Protein Expression in Blood Revealed by High Throughput Mass Spectrometry Proteomics, and Implications for Translational Medicine and Body-Time-Of-Day (BTOD). American Journal of Physiology – Regulatory Integrative and Comparative Physiology, Sep;293(3):1430-7. Epub Jun 6.
6. Martino, T.A., Tata N, Belsham DD, Straume M, Lee, P, Chalmers J, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, and Sole MJ. (2007). Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease with Rescue by Resynchronization. Hypertension, May;49(5):1104-13. Epub Mar 5.
5. Martino T, S. Arab, M. Straume, DD. Belsham, N. Tata, F. Cai, P. Liu, M. Trivieri, M. Ralph, MJ. Sole (2004). Day/night rhythms in gene expression of the normal murine heart. Journal of Molecular Medicine, 86:256-264.
4. Ayach B, Fuse K, Martino T, P. Liu (2003). Dissecting mechanisms of innate and acquired immunity in myocarditis. Current Opinion in Cardiology, 18:175-181.
3. Opavsky, M.A., T. Martino, M. Rabinovitch, C. Richardson, M. Petric, C. Trinidad, J. Penninger, and P. Liu. (2002). The extracellular signal-regulated kinase signaling cascade is a key determinant of susceptibility to coxsackievirus B3 infection and myocarditis in mice. Journal of Clinical Investigation, 109:1561-1569.
2. Martino, T.A., M. Petric, H. Weingartl, J. M. Bergelson, M. A. Opavsky, C. D. Richardson, J. F. Modlin, R. W. Finberg, K. C. Kain, N. Willis, C. J. Gauntt, and P. P. Liu. (2000). The coxsackievirus-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus. Virology, 271, 99-108.
1. Liu, P., K. Aitken, Y. Y. Kong, M. A. Opavsky, T. Martino, F. Dawood, W. H. Wen, I. Kozieradzki, K. Bachmaier, D. Straus, T. W. Mak, and J.M. Penninger. (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nature Medicine, 6, 429-434.